Bolivia has a temperate climate but temperatures can differ dramatically between day and night. The wettest period is November to March, which, in extreme circumstances, may induce landslides in mountainous areas, and cause certain roads to become impassable. The northeast slopes of the Andes are semi-tropical. Visitors sometimes find La Paz uncomfortable because of the thin air due to high altitude. The mountain areas can become very cold at night.

Lightweight, natural fabrics and waterproofs. Warmer clothing is necessary at night in the Altiplano, especially La Paz, Oruro and Potosi.